Paper submission – upload to the appropriate assignment folder by the set deadli

Paper submission – upload to the appropriate assignment folder by the set deadline.
After selecting a topic and reading both the Science Daily article (see above) and the provided peer-reviewed primary research article as a reference, please write a paper adhering to the following guidelines. Please number your answers in your paper to make sure that you’ve addressed each part of each question.
A. Title of the study you are analyzing:
B. Which observations do you think the scientists made leading up to this research study? (look for these in the scientific article Introduction)
C. Given your understanding of the experimental design, formulate a specific hypothesis that is being tested in this experiment. If a hypothesis is stated, please rewrite it IN YOUR OWN WORDS. (look for the hypothesis near the end of the scientific article Introduction)
D. Describe the experimental design including control and treatment group(s), and dependent and independent variables. (look for these in the scientific article Methods)
E. Summarize the results and the conclusion (50 points)
Criticize the research described. Things to consider: Were the test subjects and treatments relevant and appropriate? Was the sample size large enough? Were the methods used appropriate? Can you think of a potential bias in a research study like this? What are the limitations of the conclusions made in this research study? Address at least two of these questions in your critique of the research study (20 points).
Discuss the relevance of this type of research, both for the world in general and for you personally (20 points). Proper grammar will count for 10 points.
Write a paper addressing questions 1, 2, and 3 above with title page, introduction, numbered paragraphs addressing the questions, conclusion and references. As a minimum, you should have TWO references (the Science Daily article and the Journal Reference, formatted correctly in APA style). You must write in your own words and paraphrase information from the selected information sources, addressing each of the questions for your chosen topic. Your paper should consist of less than 10% direct quotes. Your paper should be 500 – 750 words, excluding references and title page. Use APA style for references, see https://www.umgc.edu/library/libhow/apa_tutorial.cfm. Spelling, punctuation, capitalization, sentence construction, and paragraph construction will be considered in the grading of this assignment. elect a topic from the article options below. Next, click on the associated link to read the Science Daily article (the peer-reviewed scholarly primary article is also provided. Use this article as needed for additional details). Finally, write a paper that addresses the three questions outlined below.
Article options (choose one):
Calorie restriction rewires metabolism, immunity for longer health span
ScienceDaily article: Pennington Biomedical Research Center. (2022, February 10). Calorie restriction rewires metabolism, immunity for longer health span. ScienceDaily. www.sciencedaily.com/releases/2022/02/220210154159.htm
Journal Reference:
Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., Ravussin, E., Galban, C., Artyomov, M. N., & Dixit, V. D. (2022). Caloric restriction in humans reveals immunometabolic regulators of health span. Science, 375(6581), 671–677. https://doi-org.ezproxy.umgc.edu/10.1126/science.abg7292
UMGC Library Permalink: http://ezproxy.umgc.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=155197981&site=eds-live&scope=site
Abstract: The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. Expression of the gene Pla2g7 encoding platelet activating factor acetyl hydrolase (PLA2G7) is inhibited in humans undergoing CR. Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, lowered NLRP3 inflammasome activation, and improved metabolic health. Therefore, the reduction of PLA2G7 may mediate the immunometabolic effects of CR and could potentially be harnessed to lower inflammation and extend the health span

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