I will need a review essay talking about Replication stress, DNA damage,and Cancer.
Main points:
1. Describe what is DNA Replication stress
talking about it from two aspect endogenous or external induced.
Describe the mechanism that cell response to Replication stress
Failed response to replication stress can result in DNA damage
2. Replication stress is a major cause of genome instability and is linked to pre-tumour and tumour cells.
How replication stress is the main driver of genome instability
How oncogenes cause replication stress.
What common mutations/oncogene activation is related to Replication stress
Replication stress and cancer, how to target replication stress in cancer cells.
Please write the essay based on the review papers (also the references in the papers) provided below. The first part can be consice, and the second part is the major part.
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