39 year-old woman come to her physician’s office with a painful swollen and tenderness in her right leg. She informed the physician her father was diagnosed as pulmonary embolus and mother as vertebral artery graft. Aft

39 year-old woman come to her physician’s office with a painful swollen and tenderness in her right leg. She informed the physician her father was diagnosed as pulmonary embolus and mother as vertebral artery graft. After physical examine, deep vein thrombosis was suspected and the coagulation tests were immediately ordered. A clotting test for APC resistance resulted in a 1.5 ratio of clotting time and an ELISA test for D-timer was positive. The patient was

immediately treated with heparin and molecular test was immediately ordered.

Focus on the following questions

Question #1: Does this patient have clotting disorder?

Question #2: What are the major causes of thrombophilia?

Question #3: What laboratory methods are useful for the diagnosis of

this patient thrombophilia?(there are several possibilities)

Question #4: Why molecular test was ordered? Lists possible molecular tests for

this patient’s condition. Compare it.

Question #5: What are the risk factors for this disease?

Question #6: Discuss any current advances in molecular diagnostics for this disease?